Cancer

Cancer

Inheriting Cancer

Cancer is a disease of the genome. During oncogenesis, mutations in genes drive cells towards the six hallmarks of cancer: self-sufficiency in growth signals, resistance to growth inhibitory signals and anti-cancer therapy, evasion of programmed cell death, unlimited replication capability, sustained ability for angiogenesis, and invasion and metastasis. Acquired mutations and inherited variations in the genome result in these cancer phenotypes by altering gene expression and cellular signaling which results in the dysregulation of molecular pathways. Dysregulation of intracellular pathways such as apoptosis (programmed cell death), cell cycle, DNA damage repair, and growth factor responses affect the processes that limit cell growth and division. Tumor cells continue to fuel their growth by promoting angiogenesis to increase vascularization and oxygenation. Tumors then expand and metastasize by altering cell adhesion and initiating epithelial-to-mesenchymal transition pathways.

However, this description implies that cancer is a homogenous disease, which scientific research has demonstrated is not the case. For example, breast cancer is classified into normal breast-like, luminal, HER2-like, and basal-like tumors based on a molecular signature. The different molecular signatures and heterogeneous phenotypes of cancer cells arise from various mutations and genetic variations. The molecular signatures in any given tumor result from combinations of mutated genes. While most of these genetic variations in tumors are mutations that are acquired over our lifetimes, inherited genetic variations account for 5-10% of the observed cases of cancer. Furthermore, inherited genetic variants also play a central role in how cancer cells and our bodies respond during therapeutic intervention.

Canon BioMedical provides a broad collection of Research Use Only (RUO) PCR genotyping assays for  cancer research that enable scientists to study the inherited genetics behind cancers and the human body’s response to therapeutic treatment.

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Novallele Genotyping Assay Search

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Novallele Genotyping Assays are ideal for obtaining genomic variation results. These assays are designed to test for single nucleotide polymorphisms (SNPs) and small insertions/deletions that have been linked to human biology. The assays are compatible with a rapid PCR protocol followed by High Resolution Melt Analysis (HRMA).

The Novallele Genotyping Assays are recommended to be used in conjunction with Novallele Genotyping Mastermix that is designed to be used with your preferred HRMA-compatible thermocycler. Use the Search Tool below to find a Novallele Genotyping Assay.

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