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Immune Disorders

Immunity and Genetic Variants

Immune disorders are disorders related to dysfunction of the immune system. They can be categorized as immune over-reaction (asthma, allergy), under-reaction (SCID, AIDS, XLA), or auto-reaction (Lupus, scleroderma, rheumatoid arthritis, multiple sclerosis, type I diabetes). These disorders can be further identified based the components of the immune system affected or by whether the condition is congenital or acquired.

Immunodeficiency disorders (under-reaction immune disorders) often compromise the immune system’s functionality, impairing the immune system's ability to defend the body against foreign or abnormal cells that invade or attack it.  As a result, unusual bacterial, viral or fungal infections or lymphomas may develop or recur more frequently. Approximately 25% of the people who are immunodeficient also have an autoimmune disorder, where the immune system attacks the body's own tissue. Oftentimes, the autoimmune disorder develops before the immunodeficiency causes any symptoms.

Both types of immune disorders can be classified as primary and secondary. Primary immune disorders usually present at birth and are usually heredity with specific single nucleotide polymorphisms (SNPs) associated with the diseases. More than 100 primary immunodeficiency disorders have been identified, with more being discovered and studied every day. Secondary immune disorders generally develop later in life as a result of other infections (such as HIV) or drug therapy that may impact the immune system's functionality. Allergic reactions are also caused by the dysfunction of the immune system, where hyper-sensitivity or over-reaction leads to the activation of Th2. Recent evidence has suggested that allergen-reactive type 2 helper T cells (Th2) play a triggering role in the activation and/or recruitment of IgE antibody-producing B cells, mast cells and eosinophils, i.e. the cellular triad involved in the allergic inflammation.

Canon BioMedical provides a broad collection of Research Use Only (RUO) PCR genotyping assays for immune disorder research that enable scientists to explore, research and identify new ways to understand these conditions related to the human body and its genetic makeup.

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Novallele Genotyping Assay Search

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Novallele Genotyping Assays are ideal for obtaining genomic variation results. These assays are designed to test for single nucleotide polymorphisms (SNPs) and small insertions/deletions that have been linked to human biology. The assays are compatible with a rapid PCR protocol followed by High Resolution Melt Analysis (HRMA).

The Novallele Genotyping Assays are recommended to be used in conjunction with Novallele Genotyping Mastermix that is designed to be used with your preferred HRMA-compatible thermocycler. Use the Search Tool below to find a Novallele Genotyping Assay.

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