AssayDetailPortlet

OPRM1 c.118A>G Novallele Genotyping Assay

Gene symbol

OPRM1 

Nucleotide change

c.118A>G 

Protein change

p.Asn40Asp

NCBI 1000 Genomes Browser

rs1799971

Assay catalog number

40046 

Control set catalog number(s)

40415

The OPRM1 c.118A>G Novallele Genotyping Assay identifies a single nucleotide change within the mu1 opioid receptor (OPRM1) in association with the 118G allele. Mutations in this gene may cause a downstream effect of reduced opioid drug metabolism. Reduced opioid drug metabolism may play a role in neurological addiction pathways.

Variant information

The OPRM1 c.118A>G Novallele Genotyping Assay is used to amplify and identify specific genetic polymorphisms or mutations. This assay provides scientists with a simple way to quickly genotype this locus from isolated human genomic DNA. The assay contains functionally-verified oligonucleotide primers necessary for PCR and subsequent allele identification by DNA melting. For Research Use Only. Not for use in diagnostic procedures.

Catalog number

 

40046 

 

Gene symbol

 

OPRM1 

Alias

 

Mediterranean Fever, MEF, pyrin, FMF, TRIM20, marenostrin, Marenostrin 

Nucleotide change

 

c.118A>G 

Protein change

 

p.Asn40Asp

Allele information

 

OPRM1, 118A-G, ASN40ASP 

Application area

 

Neuroscience

Inherited disease

Pharmacogenetics

Variant type

 

SNP

Cytogenetic location

 

6q25.2

SNP type

 

Missense 

 

NCBI 1000 Genomes Browser

 

rs1799971

dbSNP ID

 

ClinVar

 

Online Mendelian Inheritance in Man (OMIM)

 

 

PharmGKB

 

Drug interaction

 

morphine, naloxone  

Product specifications

The OPRM1 c.118A>G Novallele Genotyping Assay is compatible with any thermocycler capable of high-resolution melting (HRM). Each assay comprises a single tube containing the primers and probes optimized to detect the target. Each tube contains 600 µl, which is enough for 166 reactions. The assay is stable for 6 months at 2–8ºC.

Genotyping analysis

The OPRM1 c.118A>G Novallele Genotyping Assay identifies a SNP of c.118A>G. The graph displays the homozygous wild type in black, the heterozygous variant in blue, and the homozygous variant in red. The data were generated using the companion Novallele Control Set.

Resources

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