AssayDetailPortlet

ABCC2 c.3563T>A Novallele Genotyping Assay

Gene symbol

ABCC2 

Nucleotide change

c.3563T>A 

Protein change

p.Ile1324=

NCBI 1000 Genomes Browser

rs3740066

Assay catalog number

40207 

Control set catalog number(s)

40565

The ABCC2 c.3563T>A Novallele Genotyping Assay identifies a single nucleotide change of the ABCC2 gene. Mutations of the ABCC2 gene may result in Dubin-Johnson syndrome or fallopian tube cancer as well as multi-drug resistance. This mutation is most common in the populations of east and central Europe.

Variant information

The ABCC2 c.3563T>A Novallele Genotyping Assay is used to amplify and identify specific genetic polymorphisms or mutations. This assay provides scientists with a simple way to quickly genotype this locus from isolated human genomic DNA. The assay contains functionally-verified oligonucleotide primers and unlabeled probes necessary for PCR and subsequent allele identification by DNA melting. For Research Use Only. Not for use in diagnostic procedures.

Catalog number

 

40207 

 

Gene symbol

 

ABCC2 

Alias

 

ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2, CMOAT, Canalicular Multispecific Organic Anion Transporter 1, Multidrug Resistance-Associated Protein 2, Canalicular Multidrug Resistance Protein, MRP2 , CMRP, ATP-Binding Cassette Sub-Family C Member 2, CMOAT1, ABC30, DJS 

Nucleotide change

 

c.3563T>A 

Protein change

 

p.Ile1324=

Allele information

 

 

Application area

 

Pharmacogenetics

Cancer

Inherited disease

Variant type

 

SNP

Cytogenetic location

 

10q24.2

SNP type

 

Missense 

 

NCBI 1000 Genomes Browser

 

rs3740066

dbSNP ID

 

ClinVar

 

Online Mendelian Inheritance in Man (OMIM)

 

 

PharmGKB

 

Drug interaction

 

carbamazepine, cisplatin, cyclosporine, fluorouracil, irinotecan, leucovorin, methotrexate, mycophenolate mofetil, mycophenolic acid, oxaliplatin, tenofovir 

Product specifications

The ABCC2 c.3563T>A Novallele Genotyping Assay is compatible with any thermocycler capable of high-resolution melting (HRM). Each assay comprises a single tube containing the primers and probes optimized to detect the target. Each tube contains 600 µl, which is enough for 166 reactions. The assay is stable for 6 months at 2–8ºC.

Genotyping analysis

The ABCC2 c.3563T>A Novallele Genotyping Assay identifies a SNP of c.3563T>A. The graphs display the homozygous wild type in black, the heterozygous variant in blue, and the homozygous variant in red. The data were generated using the companion Novallele Control Set.

Resources

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