AssayDetailPortlet

CYP2D6 c.-1584C>G Novallele Genotyping Assay

Gene symbol

CYP2D6 

Nucleotide change

c.-1584C>G 

Protein change

Arg169Arg

Arg169null

Arg169Gly

NCBI 1000 Genomes Browser

rs1080985

Assay catalog number

40237 

Control set catalog number(s)

40595

The CYP2D6 c.-1584C>G Novallele Genotyping Assay identifies a single nucleotide change of the CYP2D6 gene associated with the CYP2D6*2A allele. The CYP2D6*2A allele results in normal metabolism of debrisoquine, characterized by poor synthesis of cholesterol, steroids, and other lipids.

Variant information

The CYP2D6 c.-1584C>G Novallele Genotyping Assay is used to amplify and identify specific genetic polymorphisms or mutations. This assay provides scientists with a simple way to quickly genotype this locus from isolated human genomic DNA. The assay contains functionally-verified oligonucleotide primers and unlabeled probes necessary for PCR and subsequent allele identification by DNA melting. For Research Use Only. Not for use in diagnostic procedures.

Catalog number

 

40237 

 

Gene symbol

 

CYP2D6 

Alias

 

Cytochrome P450, Family 2, Subfamily D, Polypeptide 6, CYP2DL1, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, Cytochrome P450, Family 2, Subfamily D, Polypeptide 7 Pseudogene 2, Cytochrome P450, Family 2, Subfamily D, Polypeptide 8 Pseudogene 2, Cytochrome P450, Subfamily II (Debrisoquine, Sparteine, Etc-Metabolising), Polypeptide 7 Pseudogene 2, Cytochrome P450, Subfamily IID (Debrisoquine, Sparteine, Etc-Metabolising), Polypeptide 8 Pseudogene 2, Cytochrome P450, Subfamily IID (Debrisoquine, Sparteine, Etc-Metabolizing), Polypeptide 6, Cytochrome P450-DB1, Debrisoquine 4-Hydroxylase, CYPIID6, EC 1.14.14.1, CPD6, P450DB1, CYP2D, P450-DB12, P450C2D, Cytochrome P450 2D6, Cytochrome P450, Subfamily IID (Debrisoquine, Sparteine, Etc-Metabolizing)-Like 1, Flavoprotein-Linked Monooxygenase, Microsomal Monooxygenase, Xenobiotic Monooxygenase 

Nucleotide change

 

c.-1584C>G 

Protein change

 

Arg169Arg

Arg169null

Arg169Gly

Allele information

 

CYP2D6*2A 

Application area

 

Pharmacogenetics

Variant type

 

SNP

Cytogenetic location

 

22q13.2

SNP type

 

Missense 

 

NCBI 1000 Genomes Browser

 

rs1080985

dbSNP ID

 

ClinVar

 

Online Mendelian Inheritance in Man (OMIM)

 

 

PharmGKB

 

Drug interaction

 

amitriptyline, codeine, desipramine, doxepin, fluvoxamine, imipramine, nortriptyline, oxycodone, paroxetine, selective serotonin reuptake inhibitors, tamoxifen, tramadol, trimipramine, aripiprazole, atomoxetine, clomipramine, fluoxetine, methylphenidate, mirtazapine, ondansetron, protriptyline, risperidone, sertraline, venlafaxine, carvedilol, cevimeline, clozapine, flecainide, haloperidol, metoprolol, olanzapine, propafenone, propranolol, terbinafine, tetrabenazine, thioridazine, timolol, tiotropium, tolterodine, zuclopenthixol 

Product specifications

The CYP2D6 c.-1584C>G Novallele Genotyping Assay is compatible with any thermocycler capable of high-resolution melting (HRM). Each assay comprises a single tube containing the primers and probes optimized to detect the target. Each tube contains 600 µl, which is enough for 166 reactions. The assay is stable for 6 months at 2–8ºC.

Genotyping analysis

The CYP2D6 c.-1584C>G Novallele Genotyping Assay identifies a SNP of c.-1584C>G. The graphs display the homozygous wild type in black, the heterozygous variant in blue, and the homozygous variant in red. The data were generated using the companion Novallele Control Set.

Resources

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