AssayDetailPortlet

ABCB1 c.1236T>C Novallele Genotyping Assay

Gene symbol

ABCB1 

Nucleotide change

c.1236T>C 

Protein change

p.Gly412=

NCBI 1000 Genomes Browser

rs1128503

Assay catalog number

40285 

Control set catalog number(s)

40641

The ABCB1 c.1236T>C Novallele Genotyping Assay identifies a single mutation associated with the ABCB1 gene within the subfamily of ATP binding cassettes. Mutations in this gene may be linked to resistance of anticancer drugs, antipsychotics, and antiepileptics.

Variant information

The ABCB1 c.1236T>C Novallele Genotyping Assay is used to amplify and identify specific genetic polymorphisms or mutations. This assay provides scientists with a simple way to quickly genotype this locus from isolated human genomic DNA. The assay contains functionally-verified oligonucleotide primers and unlabeled probes necessary for PCR and subsequent allele identification by DNA melting. For Research Use Only. Not for use in diagnostic procedures.

Catalog number

 

40285 

 

Gene symbol

 

ABCB1 

Alias

 

ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1, MDR1, PGY1, Multidrug Resistance Protein 1, Colchicine Sensitivity, P-Glycoprotein 1, EC 3.6.3.44, CLCS, ATP-Binding Cassette Sub-Family B Member 1 

Nucleotide change

 

c.1236T>C 

Protein change

 

p.Gly412=

Allele information

 

 

Application area

 

Pharmacogenetics

Variant type

 

SNP

Cytogenetic location

 

7q21.12

SNP type

 

Missense 

 

NCBI 1000 Genomes Browser

 

rs1128503

dbSNP ID

 

ClinVar

 

Online Mendelian Inheritance in Man (OMIM)

 

 

PharmGKB

 

Drug interaction

 

atazanavir, atenolol, clopidogrel, cyclosporine, imatinib, ritonavir, tacrolimus, tamoxifen 

Product specifications

The ABCB1 c.1236T>C Novallele Genotyping Assay is compatible with any thermocycler capable of high-resolution melting (HRM). Each assay comprises a single tube containing the primers and probes optimized to detect the target. Each tube contains 600 µl, which is enough for 166 reactions. The assay is stable for 6 months at 2–8ºC.

Genotyping analysis

The ABCB1 c.1236T>C Novallele Genotyping Assay identifies a SNP of c.1236T>C. The graphs display the homozygous wild type in black, the heterozygous variant in blue, and the homozygous variant in red. The data were generated using the companion Novallele Control Set.

Resources

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