AssayDetailPortlet

ADRB2 c.79C>G Novallele Genotyping Assay

Gene symbol

ADRB2 

Nucleotide change

c.79C>G  

Protein change

p.Gln27Glu

NCBI 1000 Genomes Browser

rs1042714

Assay catalog number

40355 

Control set catalog number(s)

No controls available

The ADRB2 c.79C>G Novallele Genotyping Assay identifies a single mutation of the ADRB2 gene. The ADRB2 gene encodes for the beta-2-adrenergic receptor, which is a member of the G protein-coupled receptor family. These receptors are primarily located in the central nervous system, heart, kidney, and muscle. Mutations of the ADRB2 gene may lead to reduced metabolism of certain respiratory and hypertension medications such as albuterol or atenolol.

Variant information

The ADRB2 c.79C>G Novallele Genotyping Assay is used to amplify and identify specific genetic polymorphisms or mutations. This assay provides scientists with a simple way to quickly genotype this locus from isolated human genomic DNA. The assay contains functionally-verified oligonucleotide primers and unlabeled probes necessary for PCR and subsequent allele identification by DNA melting. For Research Use Only. Not for use in diagnostic procedures.

Catalog number

 

40355 

 

Gene symbol

 

ADRB2 

Alias

 

Adrenoceptor Beta 2, Surface, Adrenergic, Beta-2-, Receptor, Surface, Beta-2 Adrenoreceptor, Beta-2 Adrenoceptor, ADRB2R,B2AR, Adrenoceptor Beta 2 Surface, Beta-2 Adrenergic Receptor, Catecholamine Receptor, BETA2AR, ADRBR, BAR 

Nucleotide change

 

c.79C>G  

Protein change

 

p.Gln27Glu

Allele information

 

 

Application area

 

Pharmacogenetics

Cardiovascular

Inherited disease

Variant type

 

SNP

Cytogenetic location

 

5q32

SNP type

 

Missense 

 

NCBI 1000 Genomes Browser

 

rs1042714

dbSNP ID

 

ClinVar

 

Online Mendelian Inheritance in Man (OMIM)

 

 

PharmGKB

 

Drug interaction

 

atenolol, albuterol 

Product specifications

The ADRB2 c.79C>G Novallele Genotyping Assay is compatible with any thermocycler capable of high-resolution melting (HRM). Each assay comprises a single tube containing the primers and probes optimized to detect the target. Each tube contains 600 µl, which is enough for 166 reactions. The assay is stable for 6 months at 2–8ºC.

Genotyping analysis

The ADRB2 c.79C>G Novallele Genotyping Assay identifies a SNP of c.79C>G. The graphs display the homozygous wild type in black, the heterozygous variant in blue, and the homozygous variant in red. The samples were isolated from Coriell cell lines.

Resources

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