AssayDetailPortlet

CYP2C9 c.485C>A Novallele Genotyping Assay

Gene symbol

CYP2C9 

Nucleotide change

c.485C>A 

Protein change

p.Ser162Leu

NCBI 1000 Genomes Browser

rs72558190

Assay catalog number

40792 

Control set catalog number(s)

40807

The CYP2C9 c.485C>A Novallele Genotyping Assay identifies a single nucleotide change associated with the CYP2C9*15 allele. Mutations of the CYP2C9 gene can cause reduced warfarin metabolism. Inhibited warfarin metabolism may be characterized by bleeding tendency and thromboembolic diseases such as pulmonary embolism and stroke.

Variant information

The CYP2C9 c.485C>A Novallele Genotyping Assay is used to amplify and identify specific genetic polymorphisms or mutations. This assay provides scientists with a simple way to quickly genotype this locus from isolated human genomic DNA. The assay contains functionally-verified oligonucleotide primers and unlabeled probes necessary for PCR and subsequent allele identification by DNA melting. For Research Use Only. Not for use in diagnostic procedures.

Catalog number

 

40792 

 

Gene symbol

 

CYP2C9 

Alias

 

Cytochrome P450, Family 2, Subfamily C, Polypeptide 9, CYP2C10, Cytochrome P-450MP, Cytochrome P450 PB-1, CYPIIC9, Cytochrome P450, Subfamily IIC (Mephenytoin 4-Hydroxylase), Polypeptide 9, CPC9, CYP2C, P450IIC9, Cytochrome P-450 S-Mephenytoin 4-Hydroxylase, Cytochrome P450 2C9, Xenobiotic Monooxygenase, (R)-Limonene 6-Monooxygenase, (S)-Limonene 6-Monooxygenase, (S)-Limonene 7-Monooxygenase, EC 1.14.13.-, EC 1.14.13.48, EC 1.14.13.49, EC 1.14.13.80, Cytochrome P450 MP-4, Cytochrome P450 MP-8, S-Mephenytoin 4-Hydroxylase, EC 1.14.14.1 

Nucleotide change

 

c.485C>A 

Protein change

 

p.Ser162Leu

Allele information

 

CYP2C9*15 

Application area

 

Pharmacogenetics

Cardiovascular

Variant type

 

SNP

Cytogenetic location

 

10q23.33

SNP type

 

Missense 

 

NCBI 1000 Genomes Browser

 

rs72558190

dbSNP ID

 

ClinVar

 

Online Mendelian Inheritance in Man (OMIM)

 

 

PharmGKB

 

Drug interaction

 

 

Product specifications

The CYP2C9 c.485C>A Novallele Genotyping Assay is compatible with any thermocycler capable of high-resolution melting (HRM). Each assay comprises a single tube containing the primers and probes optimized to detect the target. Each tube contains 600 µl, which is enough for 166 reactions. The assay is stable for 6 months at 2–8ºC.

Genotyping analysis

The CYP2C9 c.485C>A Novallele Genotyping Assay identifies a SNP of c.485C>A. The graphs display the homozygous wild type in black, the heterozygous variant in blue, and the homozygous variant in red. The data were generated using the companion Novallele Control Set.

Resources

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