AssayDetailPortlet

CYP2D6 c.137dupT Novallele Genotyping Assay

Gene symbol

CYP2D6 

Nucleotide change

c.137dupT 

Protein change

p.Leu47Alafs

NCBI 1000 Genomes Browser

rs774671100

Assay catalog number

40795 

Control set catalog number(s)

40810

The CYP2D6 c.137dupT Novallele Genotyping Assay identifies a duplication in the CYP2D6 gene associated with the CYP2D6*15 allele. Diseases associated with CYP2D6 include debrisoquine sensitivity and Cyp2d6-related altered drug metabolism.

Variant information

The CYP2D6 c.137dupT Novallele Genotyping Assay is used to amplify and identify specific genetic polymorphisms or mutations. This assay provides scientists with a simple way to quickly genotype this locus from isolated human genomic DNA. The assay contains functionally-verified oligonucleotide primers and unlabeled probes necessary for PCR and subsequent allele identification by DNA melting. For Research Use Only. Not for use in diagnostic procedures.

Catalog number

 

40795 

 

Gene symbol

 

CYP2D6 

Alias

 

Cytochrome P450, Family 2, Subfamily D, Polypeptide 6, CYP2DL1, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, Cytochrome P450, Family 2, Subfamily D, Polypeptide 7 Pseudogene 2, Cytochrome P450, Family 2, Subfamily D, Polypeptide 8 Pseudogene 2, Cytochrome P450, Subfamily II (Debrisoquine, Sparteine, Etc-Metabolising), Polypeptide 7 Pseudogene 2, Cytochrome P450, Subfamily IID (Debrisoquine, Sparteine, Etc-Metabolising), Polypeptide 8 Pseudogene 2, Cytochrome P450, Subfamily IID (Debrisoquine, Sparteine, Etc-Metabolizing), Polypeptide 6, Cytochrome P450-DB1, Debrisoquine 4-Hydroxylase, CYPIID6, EC 1.14.14.1, CPD6, P450DB1, CYP2D, P450-DB12, P450C2D, Cytochrome P450 2D6, Cytochrome P450, Subfamily IID (Debrisoquine, Sparteine, Etc-Metabolizing)-Like 1, Flavoprotein-Linked Monooxygenase, Microsomal Monooxygenase, Xenobiotic Monooxygenase 

Nucleotide change

 

c.137dupT 

Protein change

 

p.Leu47Alafs

Allele information

 

CYP2D6*15 

Application area

 

Pharmacogenetics

Variant type

 

Indel

Cytogenetic location

 

22q13.2

SNP type

 

Duplication 

 

NCBI 1000 Genomes Browser

 

rs774671100

dbSNP ID

 

ClinVar

 

Online Mendelian Inheritance in Man (OMIM)

 

 

PharmGKB

 

Drug interaction

 

 

Product specifications

The CYP2D6 c.137dupT Novallele Genotyping Assay is compatible with any thermocycler capable of high-resolution melting (HRM). Each assay comprises a single tube containing the primers and probes optimized to detect the target. Each tube contains 600 µl, which is enough for 166 reactions. The assay is stable for 6 months at 2–8ºC.

Genotyping analysis

The CYP2D6 c.137dupT Novallele Genotyping Assay identifies a duplication of c.137dupT. The graphs display the homozygous wild type in black, the heterozygous variant in blue, and the homozygous variant in red. The data were generated using the companion Novallele Control Set.

Resources

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